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            Recombinant Human CD207 (N-6His)
            EPT060
            規(guī)格: 價(jià)格:
            50μg ¥3000.00

            Overview

            Product name: Recombinant Human CD207 (N-6His)
            Description: Recombinant Human C-type Lectin Domain Family 4 Member K is produced by our Mammalian expression system and the target gene encoding Tyr64-Pro328 is expressed with a 6His tag at the N-terminus.
            Accession: AAH22278.1
            Molecular weight: 31.5 KDa
            Apparent molecular weight: 30-40 KDa, reducing conditions
            Purity: Greater than 95% as determined by reducing SDS-PAGE.
            Endotoxin: Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
            Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.?
            Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
            Delivery condition: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
            Background: Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.
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