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            TFE3 rabbit pAb
            
                    ES7376
                    
            
                        
            
                            
            
                                規(guī)格：
                                價(jià)格：
                            
            
                                                        
            
                                50μL
                                ￥1280.00
                            
            
                                                        
            
                                100μL
                                ￥1980.00
                            
            
                                                    
            
                    
            
                    
                
            
            
            
        
            

                
            
            
            
                
            Overview
                    文獻(xiàn)
            
                
            
                    
            
                        
            
                            
            
                                
            
                                    
            
                                        Product name:
                                        TFE3 rabbit pAb
                                    
            
                                                                            
            
                                            Reactivity:
                                            Human;Mouse
                                        
            
                                                                                
            
                                            Alternative Names:
                                            TFE3; BHLHE33; Transcription factor E3; Class E basic helix-loop-helix protein 33; bHLHe33
                                        
            
                                                                                
            
                                           Source:
                                           Rabbit
                                           
                                        
            
                                                                                
            
                                           Dilutions:
                                           Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
                                           
                                        
            
                                                                                
            
                                           Immunogen:
                                           The antiserum was produced against synthesized peptide derived from human TFE3. AA range:101-150
                                           
                                        
            
                                                                                
            
                                           Storage:
                                           -20°C/1 year
                                           
                                        
            
                                                                                
            
                                           Clonality:
                                           Polyclonal
                                           
                                        
            
                                                                                
            
                                           Isotype:
                                           IgG
                                           
                                        
            
                                                                                
            
                                           Concentration:
                                           1 mg/ml
                                           
                                        
            
                                                                                
            
                                           Observed Band:
                                           62kD
                                           
                                        
            
                                                                                
            
                                           GeneID:
                                           7030
                                           
                                        
            
                                                                                
            
                                           Human Swiss-Prot No:
                                           P19532
                                           
                                        
            
                                                                                
            
                                           Cellular localization:
                                           Cytoplasm, cytosol . Nucleus . When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity (PubMed:22692423, PubMed:30733432). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22692423, PubMed:30733432). .
                                           
                                        
            
                                                                                
            
                                           Background:
                                           This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
                                           
                                        
            
                                                                        
            
                            
            
                                                        
                                                    
            
                    
            
                
            
            
            
                        
                    
            
    
            
    




            
    
            
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